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About Dichloroacetic Acid



Chemical Names: DICHLOROACETIC ACID; 2,2-Dichloroacetic acid; 79-43-6; Dichloracetic acid; Dichloroethanoic acid; Acetic acid, dichloro-
Molecular Formula: C2H2Cl2O2 or CHCl2COOH
Molecular Weight: 128.936 g/mol
Drug Information: Therapeutic Uses  FDA UNII
Safety Summary: Laboratory Chemical Safety Summary (LCSS)


Dichloroacetic acid, often abbreviated DCA, is an acid analogue of acetic acid in which two of the three hydrogen atoms of the methyl group have been replaced by chlorine atoms. The salts and esters of dichloroacetic acid are called dichloroacetates. Salts of DCA are used as drugs since they inhibit the enzyme pyruvate dehydrogenase kinase. Early reports of its activity against brain cancer cells led patients to treat themselves with DCA, which is commercially available in non-pharmaceutical grade. A phase 1 study in 5 patients concluded that DCA was safe, but wasn’t designed to establish effectiveness. DCA was approved for use in Canada in 1989 (as a topical formulation for treatment of warts and for cauterization and removal of a wide variety of skin and tissue lesions), but was cancelled post market.


1,1-Dichloroethylene (Vinylidene Chloride)

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