|Chemical Names:||Benzo[a]pyrene; 3,4-Benzopyrene; 50-32-8; BENZO(A)PYRENE; Benzo[pqr]tetraphene; 3,4-Benzpyrene|
|Molecular Weight:||252.316 g/mol|
|Drug Information:||Therapeutic Uses FDA UNII|
|Safety Summary:||Laboratory Chemical Safety Summary (LCSS)|
Benzo[a]pyrene, also known as 3, 4-Benzopyrene or 3, 4-BP, is classified as a member of the Benzopyrenes. Benzopyrenes are organic compounds containing a benzene fused to a pyrene(benzo[def]phenanthrene) ring system. Benzo[a]pyrene is formally rated as a carcinogenic (IARC 1) potentially toxic compound. Benzo[a]pyrene is a crystalline, aromatic hydrocarbon consisting of five fused benzene rings and formed during the incomplete combustion of organic matter. Benzo[a]pyrene is primarily found in gasoline and diesel exhaust, cigarette smoke, coal tar and coal tar pitch, charcoal-broiled foods and certain other foods, amino acids, fatty acids and carbohydrate pyrolysis products, soot smoke, creosote oil, petroleum asphalt and shale oils. This substance is used only for research purposes. Benzo[a]pyrene is reasonably anticipated to be a human carcinogen (NCI05). Its diol epoxide metabolites (more commonly known as BPDE) react and bind to DNA, resulting in mutations and eventually cancer. It is listed as a Group 1 carcinogen by the IARC. In the 18th century a scrotal cancer of chimney sweepers, the chimney sweeps’ carcinoma, was already connected to soot.